The present study investigates the encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in\r\ntype 2 diabetes mellitus (T2DM) rats. The animal characteristics and biological assays of body weight, fasting blood glucose\r\n(FBG), fasting serum insulin (FINS), insulin act index (IAI), triglycerides (TG), total cholesterol (TC), high-density lipoprotein\r\ncholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured and euglycemic hyperinsulinemic glucose\r\nclamp technique were used to determine these effects. Our findings show that oral administration of encapsulated propolis can\r\nsignificantly inhibit the increasing of FBG and TG in T2DM rats and can improve IAI andMvalue in euglycemic hyperinsulinemic\r\nclamp experiment. There was no significant effects on body weight, TC, HDL-C, and LDL-C in T2DM rats treated with\r\nencapsulated propolis. In conclusion, the results indicate that encapsulated propolis can control blood glucose, modulate lipid\r\nmetabolism, and improve the insulin sensitivity in T2DM rats.
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